Your choice: Short double-stranded fragments, optimised gene sequences, complex genes or complete gene libraries
Incredible fast turnaround times
Any double stranded DNA sequence can be synthesised de novo: effectively and on schedule.
Receive brand-new synthetic genes in just 6 days - and get a head start on your individual project time table.
Make time your best friend - we will find the correct clone for you.
Unbeatable prices - from only €59
- Our GeneStrands can be ordered from as low as €59
- Receive your cloned and 100% sequence verified gene from only €99
- Complete gene libraries are starting from €309
Read more details about our service portfolio.
Curious about the myths, ranking around gene synthesis? Click here.
Choose your gene
Depending on the length and complexity of a gene or project we offer different categories of synthetic genes.
Standard genes are defined by the following criteria:
- Moderate GC content (35-75%)
- No extensive repeats (>25 bp) or critical hairpin structures
- No extensive homopolymer stretches (>18 bp)
If any of the following descriptions below match your request, our service category complex genes would be most suitable for you:
- Consultation included
- Extreme GC content (very high or low)
- Long repeats or secondary structures are part of the gene
Express genes are availabe from only 4 days and are defined by the following criteria:
- Standard Genes only
- In-house standard vector & miniprep scale
- Order must be placed before 2 p.m.
GeneStrands are a cost-efficient alternative for short genes with no complexities:
- Delivery time: starting from 5 working days
- GeneStrands lengths: 20 - 2000 bp
- Delivered as linear, double-stranded DNA fragments
Choose Gene Evolution libraries for screening projects to improve the properties of your protein of interest. We offer the following services:
- Mutations in single positions
- Mutations in multiple positions
- Mutations within specific domains
- Random substitution
One gene - millions of applications
Synthetic genes: the universal key in molecular biology
Expression improvement in heterologous systems
- Codon usage adaptation
- Promoter and enhancer elements
- cDNA cloning
- qPCR and PCR standards
Optimisation of constructs
- Introduction/removal of good and bad motifs
- Construction of hybrid genes
- Screening for improved properties of proteins
Selected publications about gene synthesis
Gene synthesis: Brieke, C. et al., Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics. Organic & biomolecular chemistry
Gene synthesis: Takeishi, R. et al., Epimerization at C-3′′ in Butirosin Biosynthesis by an NAD+-Dependent Dehydrogenase BtrE and an NADPH-Dependent Reductase BtrF. ChemBioChem
Gene synthesis: Otte, J. et al., Malonic semialdehyde reductase from the Archaeon Nitrosopumilus maritimus is involved in the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle. Aem.ASM
Gene synthesis: Buettner, K. et al., Protein surface charge of trypsinogen changes its activation pattern. BMC biotechnology 14(1)
Gene synthesis: Engeland, C. et al., CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy. Molecular Therapy 22(11)
Gene synthesis: Chiwata, R. et al., None of the Rotor Residues of F 1-ATPase Are Essential for Torque Generation. Biophysical journal 106(10)
Gene synthesis: Holmberg, M. et al., A versatile bacterial expression vector designed for single-step cloning of multiple DNA fragments using homologous recombination. Protein expression and purification 98
Gene synthesis: Dietz O. et al., Characterization of the small exported Plasmodium falciparum membrane protein SEMP1. PLOS ONE 9(7): e103272
Gene synthesis: Canali E. et al., A high-performance thioredoxin-based scaffold for peptide immunogen construction: proof-of-concept testing with a human papillomavirus epitope. Nature Scientific Reports 4(4729)
Gene synthesis: Mueller W. et al., Hierarchical organization of multi-site phosphorylation at the CXCR4 C Terminus, PLOS ONE 8(5): e64975
Gene synthesis: Van Noort, V., Bradatsch, B., Arumugam, M., Amlacher, S et al., Consistent mutational paths predict eukaryotic thermostability. BMC Evolutionary Biology, 13(1), 7
Gene synthesis: Carciofi M. et al. Concerted suppression of all starch branching enzyme genes in barely produces amylose-only starch granules. BMC Plant Biology 2012, 12:223
Gene synthesis: Lejonklou M. et al. Accelerated Proliferation and Differential Global Gene Expression in Pancreatic Islets of Five-Week-Old Heterozygous Men1 Mice: Men1 Is a Haploinsufficient Suppressor. Endocrinology April 2012 (Genes purchase/synthesis: kinase complex-associated protein (Ikbkap)
Gene synthesis: Ritari J. et al. Detection of Human Papillomaviruses by Polymerase Chain Reaction and Ligation Reaction on Universal Microarray. PLoS ONE 7(3): e34211. (HPV sequences were synthesised and cloned into plasmid vector)
Gene synthesis: Weber E. et al. Assembly of Designer TAL Effectors by Golden Gate Cloning. PLoS ONE 6(5): e19722
Gene synthesis: Gays F. et al. Comprehensive Analysis of Transcript Start Sites in Ly49 Genes Reveals an Unexpected Relationship with Gene Function and a Lack Of Upstream Promoters. PLoS ONE 6(3): e18475.